Our findings support the need to confirm this differential rate in a larger cohort of children. Vaxtracker has been adopted for active surveillance of IIV in the find more community by the AusVaxSafety consortium and expanded for use in two Australian states, New South Wales and Victoria. Sites selected include paediatric hospitals
and general practice settings. To maintain the simplicity of Vaxtracker data for clinicians the collection of additional data to provide a richer analysis, such as medical conditions, will be collected from respondents when completing the online survey. The need to ensure high quality active surveillance for safety signals when introducing new vaccines at population level has been increasingly recognised. Early experience with the Vaxtracker on-line surveillance system suggests that it provides effective post-marketing surveillance, which is ideally suited to the introduction of vaccines for children. It allowed rapid analysis of reported adverse events by public health authorities. The authors declare no conflict of interest. We thank Stephen Clarke for his assistance with the online software and database development. We would like to acknowledge the general practice clinics and Vaxtracker participants for their contribution to vaccine safety surveillance. We would also like to acknowledge Dr. Bronwen Harvey
Sunitinib manufacturer at TGA for generous advice and proof isothipendyl reading. Whilst the Australian Department of Health provided financial assistance to Hunter New England Population Health, the material contained in the reports produced by the Centre should not be taken to represent the views of the Australian Department of Health. The content of the reports is the sole responsibility of the Hunter New England Population Health. “
“Rift Valley fever virus (RVFV) is a member of the family Bunyaviridae, genus Phlebovirus. This zoonotic arbovirus, endemic to Africa
and Arabian Peninsula, causes acute disease in newborn ruminants with up to 100% fatality rate, as well as acute disease in pregnant animals resulting in abortion storms. Naturally infected animals develop high viremia sufficient to infect the arthropod vector, even if the infection is inapparent. The economically important affected species include sheep, goat, cattle and camel, with the primary route of infection being mosquito bites. Humans can be infected by mosquito bites, and importantly also by exposure to blood and tissues of infected ruminants during slaughter, necropsy or while assisting aborting animals  and . Although the disease and development of viremia in ruminants is preventable by vaccination, and ruminant vaccination is recommended to protect human population from RVFV infections, the number of RVFV vaccines in use is limited  and . Availability of a reliable challenge model is a pre-requisite for future vaccine development, registration and licensing.