The roots of tongkat ali, often called “Malaysian ginseng”, are used as an adaptogen and as a traditional “anti-aging” remedy to help older individuals adapt to the reduced energy, mood, and libido that often comes with age [3–7]. In modern dietary supplements, tongkat ali can be found in a variety of products intended to improve libido and energy, restore hormonal balance (cortisol/testosterone levels) and enhance both sports
performance and weight loss. The objective of this study was to evaluate the https://www.selleckchem.com/products/Pazopanib-Hydrochloride.html effects of tongkat ali extract on stress hormone balance (cortisol/testosterone) and psychological mood state in moderately stressed subjects. In both men and women, testosterone levels peak between 25 to 30 years of age – and thereafter drop approximately 1-2% annually [8, 9]. At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower due to stress and related lifestyle issues such as diet, exercise, and sleep patterns [10, 11]. The benefits of maintaining a youthful testosterone levels are many, including increased muscle mass and reduced body fat, high psychological vigor (mental/physical energy),
and find more improved general well-being [12, 13]. Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving Plasmin energy status and sex drive in studies of rodents [14–16]. The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG) [17, 18]. In this way, eurycoma may be considered not so much a testosterone “booster” (such as an anabolic
steroid), but rather a “maintainer” of normal testosterone levels and a “restorer” of normal testosterone levels (from “low” back “up” to normal ranges) [19]. This would make eurycoma particularly beneficial for individuals with Tucidinostat cell line sub-normal testosterone levels, including those who are dieting for weight loss, middle-aged individuals suffering with fatigue or depression, and intensely training athletes who may be at risk for overtraining [20, 21]. Traditional use Decoctions of tongkat ali roots have been used for centuries in Malaysia and Southeast Asia as an aphrodisiac for loss of sexual desire and impotence, as well as to treat a range of ailments including post-partum depression, malaria, high blood pressure, and fatigue [22].