In conclusion PPP is a pivotal procedure, as well as external stabilization, in the emergency setting, both in the OR and the ED. When patient is in extremis PPP, together with external stabilization can be life saving. Statements 1. PPP is effective in controlling hemorrhage when used as part of a multidisciplinary clinical pathway including AG and EF. [GoR B, LoE IV]   2. PPP is effective in controlling hemorrhage when used as a salvage technique.

[GoR B, LoE IV]   External fixation Background The volume of the pelvis increases after a mechanically unstable Fedratinib clinical trial pelvic fracture. EF has always been the mainstay of emergency treatment in order to reduce the volume of the pelvis and control hemorrhage [46, 48–50]. Two main techniques MAPK Inhibitor Library mw are available to externally fix the unstable

pelvic ring: external fixator and C-Clamp. While the external fixator is indicated in type B fractures, the pelvic C-clamp is used in unstable C type injuries, according to AO/OTA classification [9]. Temporary binders are used to control the hemorrhage from the pelvic fractures. These devices are very simple and quick to apply, and they can reduce the pelvic volume. However pelvic binders (PB) are not external fixator because they do not provide mechanical stabilization of the pelvis and they must be removed within 24 hours to avoid pressure sores on the patient. The data confirming efficacy of pelvic binders in controlling hemorrhage from pelvic fracture remain unclear because of conflicting studies in the literature [28, 29, 51, 52]. The Consensus Conference considered EF a pivotal see more procedure in presence of a mechanically unstable pelvic fracture and agreed that EF can be performed both in the shock room in the ED or in the OR, according to the local facilities. PB is a valid tool, mainly if applied in the prehospital setting, as a bridge to fixation. It can provide an external stabilization that could be life saving in patients in extremis. When EF is not possible (ie orthopedic surgeon is on call

during night hours) PB is a valid alternative, provided EF is accomplished as soon as possible or the patient transferred to another facility. Statements 1. PB should be applied as soon as pelvic mechanic instability is assessed, better in the prehospital setting [GoR A, LoE III]   2. Anterior or posterior EF must be accomplished in unstable fractures as soon Progesterone as possible in substitution of PB [GoR B, LoE III]   3. EF can be accomplished in the ED or in the OR and appear to be a quick tool to reduce venous and bony bleeding [GoR A, LoE IV]   4. EF, whenever possible, can be the first maneuver to be done in patients with hemodynamic instability and a mechanically unstable pelvic fracture [GoR A, LoE IV]   Angiography Background AG emerged in the ‘80s as a valid tool to control arterial bleeding [53–55] and for many years has been regarded in the vast majority of trauma centers as the first-line treatment in unstable patients.