From 1987 to 2011, 37,293 women received annual ultrasonographic screening. Women with abnormal screens underwent tumor morphology indexing, serum biomarker analysis, and surgery.
RESULTS: Forty-seven invasive epithelial ovarian cancers find more and 15 epithelial ovarian tumors of low malignant potential were detected. No women with low malignant potential tumors experienced recurrent disease. Stage distribution for invasive epithelial cancers was: stage I, 22 (47%); stage II,
11 (23%); stage III, 14 (30%), and stage IV, 0 (0%). Follow-up varied from 2 months to 20.1 years (mean, 5.8 years). The 5-year survival rate for invasive epithelial ovarian cancers detected by screening was: stage I, 95%+/-4.8%; stage II, 77.1%+/-14.5%; and stage III, 76.2%+/-12.1%. The 5-year survival rate for all women with invasive epithelial ovarian cancer detected by screening as well as interval cancers was 74.8%+/-6.6% compared with 53.7%+/-2.3% Vorinostat Epigenetics inhibitor for unscreened women with ovarian cancer from the same institution treated by the same surgical and chemotherapeutic protocols (P<.001).
CONCLUSION: Annual ultrasonographic screening of asymptomatic women achieved increased detection of early-stage ovarian cancer cases and an increase
in 5-year disease-specific survival rate for women with ovarian cancer. (Obstet Gynecol 2011;118:1212-21) DOI: 10.1097/AOG.0b013e318238d030″
“This study investigates the effect of optimized organosilane treatments on the surface properties of flax fibres and the resulting mechanical properties and interface
modifications in flax fibres reinforced poly(lactic acid) SB203580 (PLA) biocomposites. Optimizing the treatment conditions increases the hydrophobicity of the fibres, and improves significantly the mechanical properties of the biocomposites, while reducing largely the scattering. The origins of the reinforcement at the fibre/matrix interface are investigated at the macromolecular and the microstructural levels by physico-chemical and mechanical cross-analyses. It is shown that it results from both modified chemical coupling and mechanical interlocking at the fibre/matrix interface. Dynamic mechanical thermal analysis reveals a decrease in damping for treated biocomposites because of the formation of a layer of immobilized macromolecular chains resulting from strong interactions at the interface. In situ observations of crack propagation by scanning electron microscopy illustrate clearly that the treated biocomposites show a cohesive interfacial failure at much higher loads, highlighting the enhanced load transfer from the PLA to the flax fibres. (C) 2013 Elsevier B.V. All rights reserved.”
“Purpose of review
Prevention of ventricular arrhythmias and implantable cardioverter-defibrillator (ICD) therapies in patients with heart failure will be reviewed.
Recent findings
ICD utilization in patients with heart failure has resulted in significantly improved long-term survival.