Dedicated lures for this purpose have been developed ( Mands et al., 2004) and commercial traps have been produced, although the efficacy this website of these in reducing overall Culicoides biting rates (and hence arbovirus transmission risk) has not been quantified in Europe. To date, lures have not been developed for livestock-associated Culicoides species, although preliminary studies have been conducted with generic attractant compounds that show promise ( Harrup et al., 2012). In the case of C. impunctatus, these techniques are unlikely

to lead to permanent reductions in population abundance due to autogeny and huge source populations, but they may impact on the major species associated with livestock, which are largely anautogenous. In the event of an incursion of an arbovirus into Europe that is capable of person-to-person spread by Culicoides midges, education is likely to play a key role in promoting avoidance of areas supporting Ipatasertib chemical structure substantial populations of vectors. The substantial nuisance already inflicted by C. impunctatus has led to the development of a ‘midge forecast’ for tourists and local inhabitants in Scotland which is disseminated

via newspapers, a website (http://www.midgeforecast.co.uk/) and most recently a mobile phone application. Combined with data concerning C. impunctatus distribution and fine-scale habitat use, the midge forecast could be usefully employed to warn of geographical areas and habitats of high exposure risk. A clearer understanding of Anidulafungin (LY303366) which recreational activities and jobs require prolonged exposure to Culicoides would be extremely useful in qualitatively assessing risk of exposure. Overlap on farms between Culicoides populations and human workers is more difficult to assess, however, and may be significantly influenced by husbandry practices. For example, it is quite possible that those involved in forestry or game-related activities in proximity to farms may suffer greater exposure than the farmers

themselves. Culicoides are among the most abundant vectors of arboviruses found in Europe, but current evidence demonstrates that their impact on human health in this region is currently limited to biting nuisance. However, the existence of one or more proven, but as yet undescribed, route of entry for Culicoides-borne arboviruses into Europe raises the potential of future impacts on human health. From reviewing current knowledge of Culicoides populations both in Europe and in areas of arbovirus transmission worldwide we reach the following conclusions: 1. Future introduction of known or unknown arboviruses that are transmitted in epidemics between humans by Culicoides (OROV) are unlikely to lead to sustained outbreaks of disease in Europe without the involvement of additional vector groups and/or as yet unknown reservoir hosts.