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“Objectives: The involvement of autonomic imbalance has been reported in the pathogenesis of allergic diseases.
Purpose: To investigate the association between the clinical severity of childhood allergic rhinitis and autonomic nervous system (ANS) dysfunction, to define whether
the severity of disease correlates with ANS activity.
Methods: In this cross-sectional, case-control study, we evaluated the ANS testing by measuring sympathetic skin response (SRR) and heart rate (R-R) interval variation (RRIV) in 55 children with perennial allergic rhinitis (PAR), aged 7-12 yrs without any chronic co-morbidity, and the results were compared with 40 sex- and age-matched control subjects. The patients were divided into two groups according to the severity of allergic rhinitis.
Results: There were significant increase in calculated
RRIV variables during TPCA-1 cell line at rest and deep breathing in children with PAR compared to controls, which reflect parasympathetic nervous system (PNS) activity (p < 0.005). The mean amplitude of SSR in patients, which reflect sympathetic nervous system (SNS) activity was smaller compared with the controls, but this difference was not significant (0.61 +/- 0.35 mu V vs controls 0.94 +/- 0.46, p > 0.05). Lower RRIV and the prolonged SSR latencies in children with AR were closely correlated with disease severity (r = -0.65, p < 0.05, and r = -0.59, p < 0.05 respectively).
Conclusion: Combined use of these two tests, allows separate testing of PNS and SNS function, and are very sensitive methods in assessing of severity of disease in children BTSA1 cell line with PAR. PD98059 purchase (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Background: Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been
largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the role of adiponectin in younger and lean patients are limited. Therefore, the aim of the present study was to examine the association of adiponectin levels in young and lean women with PCOS.
Methods: A case-control study was conducted at the Dow University of Health Sciences, Karachi, Pakistan. Cases were 75 patients of PCOS with Body Mass Index (BMI) <23 aged 16-35 years and 75 healthy age and BMI matched controls were selected from family and friends of the cases. Demographic details, family history and past medical history were obtained through interview by a physician. Anthropometric measurements included weight and height of the participants. Fasting glucose, total cholesterol, high-density lipoprotein (HDL), insulin, adiponectin, and androgen levels were determined. IR was calculated using homeostasis model assessment for insulin resistance (HOMA-IR). Logistic regression models were used to assess the association between adiponectin and PCOS after adjusting for co-variates.