An initial search of the databases CINAHL, Education Database, and Education Research Complete, focused on locating related publications from 2010 to 2020, retrieved a total of 308 articles. read more Upon completion of the screening and eligibility process, 25 articles were critically appraised. Matrices were constructed from the extracted article data for categorization and comparison.
A foundational analysis highlighted three key themes, accompanied by their related sub-themes, employing foundational concepts to define student-centric learning, eligibility requirements, amplifying student knowledge, honing student competencies, promoting student self-sufficiency and personal growth, incorporating peer-based learning, independent learning, and teacher-supported learning.
In nursing education, a student-centered approach fosters learning where educators facilitate student autonomy, empowering learners to direct their own educational journey. Students gather in study groups, where the teacher attentively monitors and responds to their academic needs. Improving students' theoretical and practical understanding, developing their problem-solving and critical-thinking abilities, and promoting self-reliance are all reasons to adopt a student-centered learning approach.
Nursing education's student-centered learning model positions the teacher as a facilitator, empowering students to direct their own educational journey. Learning in collaborative groups allows students to study together and have their needs heard and addressed by their teacher. The key benefits of student-centered learning include deepening students' grasp of theoretical and practical knowledge, improving their adaptability in problem-solving and critical thinking, and fostering self-sufficiency.

Stress-induced dietary changes, including overeating and less healthy choices, are recognized; yet, the relationship between particular parental anxieties and fast-food intake amongst parents and their young children remains under-investigated. We posited a positive correlation between parental perceived stress, parenting-related stress, and household disorganization and the frequency of fast-food consumption by parents and their young children.
Individuals who are parents of toddlers and preschoolers (ages two to five), and whose BMI is greater than 27 kg/m²
A survey of 234 parents, having a mean age of 343 (standard deviation 57), and their children (mean age 449 months, standard deviation 138), mainly from two-parent households (658%), assessed their perceptions of parental stress, parenting stress, household disorganization, and their respective fast-food intake.
Across multiple regression models, controlling for various covariates, a significant relationship is observed between parent-perceived stress and the outcome variable (β = 0.21, p < 0.001; R-squared value).
Parenting stress and the outcome were strongly correlated (p<0.001), a pattern repeated with statistically significant correlations (p<0.001) in additional factors.
A profound statistical relationship between variable one and the outcome (p < 0.001) was observed, along with a noteworthy escalation in household chaos (p < 0.001), potentially indicating a link between these variables (R).
Parent perceived stress levels were significantly associated with parent fast-food consumption (p=0.005), and showed a separate significant association with child fast-food consumption (p=0.002).
A very strong and statistically significant link was established between the outcome and parenting stress (p < 0.001), and a strong association with another stressor was observed (p = 0.003).
A strong, statistically significant correlation (p<0.001) was found between parent fast-food consumption and the outcome, further demonstrated by the correlation coefficient (p<0.001; R=.).
The experiment yielded a statistically powerful result (p<0.001, effect size of 0.27). The final, comprehensive models showed that parenting stress (p<0.001) was the only substantial predictor of parent fast-food consumption, which uniquely predicted child fast-food consumption (p<0.001).
The research findings advocate for parenting stress interventions tailored to address fast-food eating habits in parents, thereby potentially diminishing fast-food consumption by their children.
Parenting stress interventions focusing on curbing fast-food consumption in parents are supported by the findings, potentially decreasing fast-food intake in their young children.

The tri-herb combination of Ganoderma (dried fruiting body of Ganoderma lucidum), Puerariae Thomsonii Radix (dried root of Pueraria thomsonii), and Hoveniae Semen (dried mature seed of Hovenia acerba), known as GPH, has been utilized in the treatment of liver damage; however, the precise pharmacological underpinnings of this GPH use remain elusive. To ascertain the liver-protective effects and underlying mechanisms, an ethanolic extract of GPH (GPHE) was investigated in mice within this study.
Quality control of the GPHE extract involved the quantification of ganodermanontriol, puerarin, and kaempferol using the method of ultra-performance liquid chromatography. Researchers utilized an ICR mouse model of ethanol-induced liver injury (6 ml/kg, intra-gastric administration) to investigate the hepatoprotective activity of GPHE. Bioassays and RNA-sequencing analysis were employed to elucidate the mechanisms of action associated with GPHE.
The respective concentrations of ganodermanontriol, puerarin, and kaempferol in GPHE were 0.632%, 36.27%, and 0.149%. Daily, by way of illustration. Fifteen days of GPHE treatment, at 0.025, 0.05, or 1 gram per kilogram dosages, countered the ethanol-induced (6 ml/kg, i.g. on day 15) elevation of serum AST and ALT and led to better histological conditions in mouse liver. This indicates a protective role for GPHE in mice against ethanol-related liver injury. Mechanistically, GPHE suppressed Dusp1 mRNA levels (coding for the mitogen-activated protein kinase inhibitor MKP1) and elevated the expression and phosphorylation of the mitogen-activated protein kinases JNK, p38, and ERK, which are crucial for cell survival within the context of mouse liver tissue. GPHE resulted in enhanced PCNA (a cell proliferation marker) expression and a decrease in the number of TUNEL-positive (apoptotic) cells within the mouse livers.
GPHE's function in protecting against ethanol-induced liver injury is associated with its modulation of the MKP1/MAPK signaling system. This investigation provides pharmacological backing for the use of GPH to treat liver injury, and indicates the potential of GPHE for becoming a cutting-edge medication for the management of liver damage.
GPHE's protective function against ethanol-induced liver damage is correlated with its role in regulating the MKP1/MAPK signaling pathway. read more Pharmacological evidence from this study supports the use of GPH in addressing liver injury, and suggests the possibility of GPHE becoming a modern medication for the management of liver injury.

Pruni semen, a traditional herbal laxative, may feature Multiflorin A (MA) as a potential active ingredient. Its unusual purgative activity and unclear mechanism present an intriguing area of study. Inhibiting intestinal glucose absorption shows promise as a novel laxative mechanism. Yet, this mechanism remains unsupported by the absence of fundamental research explanation and support.
This study sought to ascertain the primary role of MA in the purgative action of Pruni semen, examining the intensity, nature, location, and mechanism of MA's effect in mice, while also exploring the novel mechanism of traditional herbal laxatives regarding intestinal glucose absorption.
By administering Pruni semen and MA, we induced diarrhea in mice, and subsequently analyzed defecation behavior, glucose tolerance, and intestinal metabolism. An in vitro intestinal motility assay was applied to explore the influence of MA and its metabolite on the peristalsis observed in intestinal smooth muscle. The research investigated the expression of intestinal tight junction proteins, aquaporins, and glucose transporters with immunofluorescence. The 16S rRNA sequencing and liquid chromatography-mass spectrometry methods were used to analyze the gut microbiota and fecal metabolites.
The experimental mice treated with MA (20mg/kg) displayed watery diarrhea in over fifty percent of cases. MA's purgative effect, synchronized with its capacity to lower peak postprandial glucose levels, relied on the acetyl group as its active moiety. MA's metabolic activity was most pronounced in the small intestine. This activity was associated with a reduction in the expression of sodium-glucose cotransporter-1, occludin, and claudin1, which then prevented glucose absorption and led to a hyperosmotic condition. MA worked to elevate aquaporin3 expression, contributing to water secretion. Changes in the gut microbiota and their metabolic processes in the large intestine, driven by unabsorbed glucose, lead to increased gas and organic acid production, thereby facilitating defecation. Recovery resulted in the reinstatement of intestinal permeability and glucose absorption capacity, and a corresponding increase in the abundance of probiotics such as Bifidobacterium.
MA's purgative action involves inhibiting glucose absorption, altering the permeability and function of water channels to facilitate water discharge from the small intestine, and modulating gut microbiota metabolism in the large intestine. This study marks the first systematic, experimental examination of the purgative consequences associated with MA. read more New light is shed on the study of novel purgative mechanisms through our findings.
MA's purgative mechanism is a complex process involving the inhibition of glucose absorption, alterations in the permeability and function of water channels to promote water release in the small intestine, and the modulation of gut microbiota metabolism in the large intestine.