The consideration of how material properties change in diseases could lead to a new paradigm that may expand beyond the focus on biochemical readings alone and include a characterization of material properties in diagnosis and treatment, an effort referred to as materiomics.”
“To survive in a complex world, it is important that unattended, but salient, input can still draw one’s attention. In this article, we suggest that posterior alpha oscillations LDK378 (8-13 Hz) provide a mechanism for prioritizing and ordering unattended visual input according to ‘relevance’. Gamma oscillations (30-100 Hz) that are phase-locked to the alpha

oscillations keep competing unattended representations apart in time, thus creating a sequence of perceptual cycles. As inhibition gradually lowers within an alpha cycle, the ordered sequence of competing input is activated, producing a temporal phase code for saliency. The proposed mechanism is based on recent experiments indicating that the phase of alpha activity modulates perception and that alpha oscillations are produced by periodic pulses of inhibition.”
“The influenza virus

transcribes and replicates its genome inside the nucleus of infected cells. Both activities are performed by the viral RNA-dependent RNA polymerase that is composed of the three subunits PA, PB1, and PB2, and recent studies have shown that it DAPT price requires host cell factors to transcribe and replicate the viral genome. To identify these cellular partners, we generated a comprehensive physical interaction map between each polymerase subunit and the host cellular proteome. A total of 109 human interactors were identified by yeast two-hybrid screens, whereas 90 were retrieved by literature mining. We built the FluPol interactome network composed of the influenza virus polymerase (PA, PB1, and PB2) and the nucleoprotein NP and 234 human proteins that are connected through 279 viral-cellular protein interactions. Analysis of this interactome map revealed enriched cellular functions associated with the influenza virus polymerase, including

host factors involved in RNA polymerase II-dependent transcription and for mRNA processing. We confirmed that eight influenza virus polymerase-interacting proteins are required for virus replication and transcriptional activity of the viral polymerase. These are involved in cellular transcription (C14orf166, COPS5, MNAT1, NMI, and POLR2A), translation (EIF3S6IP), nuclear transport (NUP54), and DNA repair (FANCG). Conversely, we identified PRKRA, which acts as an inhibitor of the viral polymerase transcriptional activity and thus is required for the cellular antiviral response.”
“To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs.