Published by Elsevier FK506 PI3K/Akt/mTOR inhibitor Ltd. All rights reserved.”
“Human embryo vitrification is a promising new technology but clinical outcome data is needed to gauge its effectiveness and safety. While pregnancy and live-birth data is available for blastocyst vitrification, such information is lacking for human embryo vitrification at the 6- to 8-cell
stage. The current work presents clinical and obstetric outcomes from the transfer of embryos vitrified on day 3 at the cleavage stage. A total of 270 transfers were performed. The clinical pregnancy and implantation rates for patients under 38 years of age (n = 200) were 45% and 24%, respectively. Corresponding rates in patients 38-42 years old declined to 29% and 13% (n = 70). Embryonic compaction and/or blastulation by the time of transfer were excellent prognostic indicators of a successful pregnancy outcome. Of the 66 deliveries, 12 (18.2%) were twin pregnancies and nine were preterm (13.6%). The mean birthweight for singletons was
3281 +/- 644 g, compared with 2506 +/- 549 g in the twin pregnancies. A total of 78 infants have been born with no major congenital malformations. These data attest to the efficacy and safety of the vitrification technique for cryopreservation of human embryos at the 6- to 8-cell stage. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. Acadesine price All rights reserved.”
“The role of acupuncture on the pregnancy rate has not been evaluated in frozen thawed embryo transfer (FET) cycles. selleck products This randomized double-blind study aimed to determine whether acupuncture
performed on the day of FET improves clinical outcomes. On the day of FET, 226 patients were randomly allocated to either real or placebo acupuncture according to a computer-generated randomization list in sealed opaque envelopes. They received a session of real or placebo acupuncture for 25 min on site immediately after FET. The anxiety level and serum cortisol concentration were evaluated before and after real and placebo acupuncture. There were no significant differences in rates of overall pregnancy, clinical pregnancy, ongoing pregnancy, live birth and implantation in the placebo acupuncture group, when compared with the real acupuncture group. The anxiety level and serum cortisol concentration were similar for both groups. Only the placebo acupuncture group had significantly higher ongoing pregnancy (P = 0.022) and implantation rates (P = 0.038) than those who declined to join the study and received no acupuncture. In conclusion, comparable pregnancy and live birth rates of FET treatment were found in patients who had one session of real or placebo acupuncture after FET. (C) 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.