Objective: We studied the effect of APOE genotype disclosure for AD risk assessment on dietary supplement use in adults with a family history of AD.

Design: Autophagy inhibitor As part of a secondary analysis of data from the second Risk Evaluation and Education for Alzheimer’s Disease Study, we examined the effect of genotype disclosure on health-behavior changes among 272 unaffected first-degree relatives of persons

with AD.

Results: Overall, 16% of all participants reported a change in dietary supplement use after AD risk assessment. Participants who learned that they had at least one copy of the risk-increasing epsilon 4 allele (epsilon 4+) had 4.75 times the odds of reporting a change in dietary supplement use than did their counterparts who had an absence of the risk-increasing epsilon 4 allele (epsilon 4-) (95% CI: 2.23, 10.10; P < 0.0001) after adjustment for age, sex, race, baseline supplement use, randomization arm, and educational level. There were no significant differences between APOE epsilon 4+ and epsilon 4- participants in changes in overall diet, exercise, or medications.

Conclusions: In this sample of first-degree relatives receiving genetic susceptibility testing for AD, an APOE epsilon 4+ genotype status was positively associated

with dietary supplement use after risk disclosure. selleck products Such changes occurred despite the absence of evidence that supplement use reduces the risk of AD. Given the expansion of DTC genetic tests, this study highlights the need for future studies in disease risk communication. Am J Clin Nutr 2010;91:1402-7.”
“BACKGROUND: Pulmonary non-tuberculous mycobacterial (NTM) infection is relatively common after lung transplantation, but the effect on mortality remains undetermined. this website Herein we describe our experience with pulmonary NTM infection after lung transplantation and hypothesized that non-tuberculous mycobacterial infection after lung transplantation would be associated with increased mortality.

METHODS: We retrospectively evaluated 201 primary lung transplant recipients transplanted between January 2000 and August 2006. Serial bronchoscopies with bronchoalveolar lavage and transbronchial biopsy were performed according to a surveillance

protocol and when clinically indicated. The diagnosis NTM infection was established by a positive NTM culture in a bronchoalveolar lavage sample or in at least two separate expectorated sputum samples. NTM infections were further classified as “”disease”" or “”colonization,”" based on whether or not NTM infection patients developed symptoms and characteristic radiographic findings.

RESULTS: Thirty-six (18%) recipients were diagnosed with pulmonary NTM infection at a median of 97 days post-transplantation: 9 were classified as NTM disease and the remaining 27 as NTM colonization cases. Single lung transplant was a significant risk factor for NTM infection (HR 2.25, p = 0.02). NTM colonization was a risk factor for NTM disease (HR 8.39, p = 0.003).