Lung Cancer 2007, 55:205–213.PubMedCrossRef 64. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O’Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J: miR-24 inhibits cell

proliferation Cyclosporin A price by targeting E2F2, MYC, and other cell-cycle genes via binding to “”seedless”" 3′UTR microRNA recognition elements. Mol Cell 2009, 35:610–625.PubMedCrossRef 65. Duursma AM, Kedde M, Schrier M, le Sage C, Agami R: miR-148 targets human DNMT3b protein coding region. RNA 2008, 14:872–877.PubMedCrossRef 66. Le X, Merchant O, Bast RC, Calin GA: The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade. Cancer Microenvironment 2010, in press. 67. Garofalo M, Quintavalle CP-868596 order C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM, Condorelli G: MicroRNA signatures of TRAIL

resistance in human non-small cell lung cancer. Oncogene 2008, 27:3845–3855.PubMedCrossRef 68. Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC: MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci USA 2009, 106:12085–12090.PubMedCrossRef 69. Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E: Uncovering growth-suppressive microRNAs in lung cancer. Clin Cancer Res 2009, 15:1177–1183.PubMedCrossRef 70. Mascaux C, Laes JF, Anthoine G, Haller A, Ninane V, Burny A, Sculier JP: Evolution of microRNA expression during human bronchial squamous carcinogenesis.

Eur Respir J 2009, 33:352–359.PubMedCrossRef 71. Nasser MW, Datta J, Nuovo G, Kutay H, Motiwala T, Majumder S, Wang B, Suster S, Jacob ST, Ghoshal Megestrol Acetate K: Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1. J Biol Chem 2008, 283:33394–33405.PubMedCrossRef 72. Zhao Y, Samal E, Srivastava D: Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature 2005, 436:214–220.PubMedCrossRef 73. Phelps RM, Johnson BE, Ihde DC, Gazdar AF, Carbone DP, McClintock PR, Linnoila RI, Matthews MJ, Bunn PA Jr, Carney D, Minna JD, Mulshine JL: NCI-Navy Medical Oncology Branch cell line data base. J Cell Biochem Suppl 1996, 24:32–91.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions JDM and AFG derived the cell lines, LG isolated the RNA, SMH ran the arrays, and JJS and I performed data analysis. LD and AP designed the study, analyzed the data and wrote the manuscript. All authors read and approved the final manuscript.