Overall, SVR-24 rates in the RGT arms (A-C) ranged from 32.9% to 48.8% and overall relapse rates ranged from 33.9% to 51.8% (Fig. 3). SVR-24 rates among patients who achieved an eRVR and discontinued treatment at week 24 in arms A, B, and C were 61.3%, 62.8%, and 40.8%, respectively, which were higher than those in patients who did not achieve an eRVR and received 48 weeks of treatment (40.8%, 18.4%, and 21.2%, respectively). Relapse

rates among patients who achieved an eRVR and discontinued treatment at week 24 in arms A, B, and C were 36.7%, 37.2%, and 57.4%. In comparison, relapse rates among patients who did not achieve 3-Methyladenine in vivo AZD5363 mouse an eRVR and who were assigned to 48 weeks of treatment were 31.0%, 41.7%, and 22.2%, respectively. The pattern of VR rates in patients without and with cirrhosis were

consistent with overall results. In both subgroups, VRs at weeks 4 and 12 were higher in each of the mericitabine treatment arms than in the placebo arm (Fig. 4A,B). Among patients treated with mericitabine 1,000 mg/day in arms B, C, and D, 64.1%-69.0% of patients without cirrhosis and 47.8%-55.6% of patients with cirrhosis achieved an RVR at week 4. In contrast, an RVR was achieved by 21.5% of patients without cirrhosis and 5.3% of patients with cirrhosis in the placebo control arm. SVR-24 rates in patients without and with cirrhosis treated with mericitabine 1,000 mg in arm D were 56.9% and 30.4%, respectively, and 46.2% and 47.4%, respectively, in the placebo control arm (Fig. 4A,B). Relapse rates in patients without and with cirrhosis were 26.1% and 41.7%, respectively, in group D and 31.3% and 30.8%, respectively,

in the placebo control arm. IL28B genotype was available for 245 of 408 patients (60.0%; Table 1). Among patients treated with mericitabine 1,000 mg BID in arms B, C, and D, an RVR medchemexpress was achieved by 83.3%-100% of CC patients (Fig. 5A) and 45.9%-54.5% of non-CC patients (Fig. 5B). In comparison, an RVR was achieved by 25.0% and 8.8% of CC and non-CC patients, respectively, in the placebo control arm. SVR-24 and relapse rates in arm D were 90.9% and 0% among CC patients (Fig. 5A) and 29.5% and 51.9% among non-CC patients (Fig. 5B). In comparison, SVR-24 and relapse rates in the placebo control arm were 58.3% and 41.7% among CC patients (Fig. 5A) and 41.2% and 36.4% among non-CC patients (Fig. 5B). Patients treated with mericitabine in the RGT arms (B and C) had lower SVR rates and higher relapse rates than patients in arm D. This reflects the shorter duration of therapy in patients with an eRVR in arms B and C. Of 21 G4 patients randomized to treatment with mericitabine in arms A-D, 14 achieved an SVR, including 7 of 9 patients who received mericitabine 1,000 mg BID for 12 weeks in arms C and D.