Dr. Sara F.L. Kirk acknowledges the support from a CIHR Canada Research Chair in Health Services Research and an IWK Scholar Award. Ms. Jessie-Lee D. McIsaac acknowledges the support from a Vanier Canada Graduate Scholarship (CIHR). The

authors would like to thank stakeholders from the Nova Scotia Government and Nova Scotia School Boards as well as schools, parents and students for their participation in this research. The authors declare that there are no conflicts of interest. All interpretations and opinions in the present study are those of the authors. This work is dedicated to the memory of Hannah Carmichael. “
“Poor health is associated with poorer living circumstances (Clark et al., 2007, Croucher et al., 2007, Davison and Lawson, 2006, Ellaway et al., 2012, Meijer et al., 2012, Renalds et al., 2010, Truong BMS-387032 cost and Ma, 2006 and Yen et al., 2009) and there is therefore, an expectation that housing improvements and area regeneration Autophagy inhibitor in disadvantaged urban areas will improve health and reduce social inequalities in health (Kearns et al., 2009 and WHO Commission on

Social Determinants of Health, 2008). Urban regeneration can thus be considered a public health intervention (PHI) whereby improvements in health and wellbeing are stated as specific aims of regeneration strategies (Beck et al., 2010). Regeneration generally includes a range of activities that may potentially improve the interlinked dimensions of household, dwelling, community and neighborhood environment in urban areas, thereby impacting on many of the social determinants of health (Dahlgren and Whitehead, 2007). However, to date the evidence that regeneration activities achieve these health benefits is limited or weak and any health effects are small (Jacobs et al., 2010 and Thomson et al., 2009). Evidence for long-term effects and the mechanisms by which different interventions or combinations of interventions might lead to positive health

outcomes tend also to be absent (Atkinson et al., 2006, Jacobs et al., 2010, Lindberg et al., 2010 and Thomson et al., 2006). There are also concerns that regeneration activities may have unintended consequences of social disruption and displacement Liothyronine Sodium through gentrification (Fullilove, 2004, Huxley et al., 2004, Lindberg et al., 2010 and Paris and Blackaby, 1979). Undertaking an evaluation of regeneration is difficult — these are complex interventions not easily suited to being assessed using RCT methods. In the USA two well-researched regeneration programs have used random allocation. The Gautreaux 1 Program used a quasi-random allocation of households to suburban locations (Rubinowitz and Rosenbaum, 2000). Informed by this program the Moving to Opportunity Demonstration used random allocation to experimental, comparison and control groups for relocation purposes (Briggs et al., 2010).