Design-Retrospective case series.

Animals-225 dogs (yielding 225 S schleiferi isolates).

Procedures-Information obtained from affected dogs’ medical

records included isolate body site source, antimicrobial treatments, and primary disease. For each dog, the S schleiferi isolate was characterized and antimicrobial susceptibility data were recorded. Risk factors for infection based on coagulase status and for S schleiferi oxacillin resistance were investigated. Results-Allergic dermatitis was the most common underlying disease (111/225 dogs). Ears (102 [45%])) and skin (95 [42%]) were sources selleck screening library of most of the 225 isolates. Isolate coagulase status was not significantly associated with any patient-level factors. Of the 225 isolates, 129 (57%) were oxacillin resistant. Coagulase-negative isolates were more likely to be oxacillin resistant than were coagulase-positive isolates (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1 to 3.0). Administration AZD8055 purchase of penicillin-based or first-generation cephalosporin drugs (OR, 3.0; 95% Cl, 1.8 to 5.9) and third-generation cephalosporins (OR, 3.7; 95% Cl, 1.1 to 12.3) within 30 days prior to culture were risk factors for oxacillin resistance.

Conclusions and Clinical Relevance-Results suggested that coagulase-negative and coagulase-positive S schleiferi are potential pathogens in dogs and are often oxacillin

resistant. Recent patient treatments with penicillin or cephalosporin were risk factors for oxacillin resistance. In clinical cases, full speciation of all Staphylococcus isolates should be performed and microbial treatments should be selected on the basis of results of susceptibility testing. (J Am Vet Med Assoc

2011239:1566-1573)”
“Background: Chromophobe renal cell carcinoma is a category of renal cell carcinoma composed of histologically characteristic tumor cells. selleck kinase inhibitor E-cadherin is an intercellular adhesion protein that has been correlated with tumor aggressiveness in many carcinomas, including clear cell renal cell carcinoma. However, the significance of an E-cadherin expression in chromophobe renal cell carcinoma is not known. Methods : We evaluated the E-cadherin expression status of 65 chromophobe renal cell carcinomas by performing immunohistochemical staining with the tissue microarray method. The percentage of positively stained tumor cells was evaluated and this was then classified into two categories: a low expression where 0 to 25% of the cells are positive, and a high expression where more than 25% of the cells are positive. Results : Among 65 cases, 11 cases (17%) showed a low expression, and 54 cases (83.0%) showed a high expression. The tumors with low expression were more likely to have a higher stage but this was not significant (p=0.056).