Demographic information, angiographic variables, and types of endovascular interventions were recorded. The mean transit time and cerebral blood volumes
were recorded for the ipsilateral and contralateral middle cerebral artery territories. A binary logistic regression model was constructed see more to determine the independent predictors of developing intracranial hemorrhage.
RESULTS: A total of 57 patients (33 from the University of Pittsburgh and 24 from Michigan State University) with a mean age of 66 +/- 13 years and mean National Institutes of Health Stroke Scale scores of 16 +/- 5 were studied. The overall recanalization (Thrombolysis in Myocardial Infarction Trial scale 2 or 3 flow) was 72% for the cohort, and the overall rate of parenchymal hemorrhage was 5 of 57 (9%) patients. The overall hemorrhage rate was 19 of 57 (33%) patients. The only variable found to be predictive of the development of hemorrhage after intervention was reduced pretreatment cerebral blood volume (odds ratio, 0.49; 95% confidence interval, 0.35-0.91; P
< 0.022).
CONCLUSION: A reduced pretreatment ipsilateral cerebral LY2835219 blood volume value before endovascular revascularization of an acute middle cerebral artery or internal carotid artery occlusion significantly increases the risk of an intracranial hemorrhage.”
“Aims: Proton motive force (PMF) inhibition enhances the intracellular accumulation of autoinducers possibly find more interfering with biofilm formation. We evaluated the effect of the PMF
inhibitor carbonyl cyanide-m-chlorophenylhydrazone (CCCP) on Pseudomonas aeruginosa biofilm development.
Methods and Results: Four epidemiologically unrelated P. aeruginosa isolates were studied. A MexAB-oprM overproducing strain was used as control. Expression of gene mexB was examined and biofilm formation after incubation with 0, 12.5 and 25 mu mol l(-1) of CCCP was investigated. Mean values of optical density were analysed with one-way analysis of variance and t-test. Two isolates subexpressed mexB gene and only 25 mu mol l(-1) of CCCP affected biofilm formation. Biofilms of the other two isolates and control strain PA140 exhibited significantly lower absorbance (P ranging from < 0.01 to < 0.05) with either 12.5 or 25 mu mol l(-1) of CCCP.
Conclusions: The PMF inhibitor CCCP effect was correlated with the expression of MexAB-OprM efflux system and found to compromise biofilm formation in P. aeruginosa.
Significance and Impact of the Study: These data suggest that inhibition of PMF-dependent trasporters might decrease biofilm formation in P. aeruginosa.”
“OBJECTIVE: Barbiturate-induced coma can be used in patients to treat intractable intracranial hypertension when other therapies, such as osmotic therapy and sedation, have failed.