Control, 2. Stress, 3. Leptin (10 mu g/kg leptin, i.p. twice a day, for 7 days), 4. Leptin + stress. At the end of 7(th) day Stress and Leptin + stress groups were exposed to cold-restraint stress, inflicted by placing the animals in a refrigerator at 4.0 degrees +/- 0.5 degrees C for 4 h. At the end of the experiments animals were killed under thiopental sodium (50mg/kg) anesthesia. Plasma and liver malondialdehyde, glutathione and total nitric oxide levels were measured.\n\nResults: Cold-restraint stress increased plasma and liver malondialdehyde levels whereas decreased glutathione and total nitric oxide levels. Pretreatment with leptin significantly lowered malondialdehyde levels

and elevated glutathione and total nitric oxide levels.\n\nConclusions: Acute cold stress may lead to oxidative stress by increasing the lipid peroxidation

while depleting the antioxidant capacities. Preteatment with leptin exerted a protective effect on plasma and INCB018424 liver against cold restraint SNX-5422 cell line stress induced tissue injury, probably through increasing nitric oxide content.”
“Recent health care improvement initiatives have linked financial payments to compliance with predetermined performance measures. This article reports the effect of a unique prophylactic antibiotic use program on compliance rates and costs. The Departments of Surgery, Infection Control, and Anesthesiology collaborated on a prophylactic preoperative antibiotic protocol, whereby Anesthesiology assumed responsibility for timely PLX4032 inhibitor antibiotic prophylaxis (TAP) before surgical incision. Data from January 1, 2008, to December 31, 2008, were compared (z test) with the 12-month period before this

change. chi(2) Analysis identified factors associated with TAP. Return on investment (ROI) was calculated. TAP compliance rates increased from 75.1% to 89.3% (P < .001) following program implementation. Factors associated with TAP failure included >60 minutes from anesthesia induction to surgical incision (P < .001), surgical procedure (P < .001), specific antibiotic administered (P < .001), and individual anesthesia provider (P < .001). The ROI was 2.2. TAP compliance rates increased after Anesthesiology assumed responsibility, with anesthesia providers being a significant factor.”
“The Alzheimer’s Association International Conference on Alzheimer’s disease (AD) 2014 took place in Copenhagen, Denmark, and brought together experts in dementia and AD research. The conference offered a platform for researchers from industry and academia to network and discuss the most recent discoveries in the field, with the common aim to ultimately find a cure for AD. This report highlights developments in imaging agents and novel treatments for AD.”
“This article reports two cases of scrotum Paget’s disease in two biological brothers who were admitted and treated in our hospital in 2013. They are very rare cases.