A total of 266 participants with rLTNCs completed the survey. The HRQL of patients is substantially reduced compared to the general population. Many patients reported pain, were anxious or depressed and experienced problems with
see more mobility, self-care and usual activities (mean EQ-5D index scores ranged from 0.2 to 0.44). Although some patients have accessed rehabilitative services, results suggest care coordination could be improved.
Rare long-term neurological conditions have a significant impact on HRQL. Many patients with rLTNCs do not seem to be accessing the level of health and social care services that could improve their HRQL.”
“Study Design. A consecutive series of 19 cases of solitary plasmacytoma (SP) of cervical spine that underwent surgical treatment and one case that underwent pure radiotherapy
were observed from 1995 to 2006.
Objective. To discuss the clinical characteristics, therapeutic methods and factors affecting prognosis of SP in the cervical spine.
Summary of Background Data. SP of bone is a rare plasma cell tumor which represents the proliferation of monoclonal plasma cells without evidence of significant bone marrow plasma cell learn more infiltration. Although radical radiotherapy is the treatment of choice for SP of the bone, recommendations for treatment methods of this disease have been solely based on limited data from retrospective studies.
Methods. Data of 20 patients with SP of the cervical spine that were identified and treated between January 1995 and December 2006 were reviewed retrospectively. There were 13 men and 7 women ranging in age from 32 to 76 years with a mean of buy PF-02341066 56 years. Among
them, 1 patient underwent radiotherapy alone, and the other 19 patients received surgery with adjuvant radiotherapy. According to the Weinstein-Boriani-Biagini staging system, the surgical procedures consisted of subtotal resection and gross-total resection. All cases were managed using an anterior approach or a combined anterior and posterior approach in 1 stage. Reconstruction of the cervical spine was achieved through an anterior cervical titanium plate and titanium mesh cage filled with autoiliac graft or bone cement, or anterior and posterior combined instrumented fusion. All surgery patients received radiotherapy as adjunctive therapy postoperatively.
Results. Follow-up of the 20 patients ranged from 25 to 132 months with a mean of 61 months. Neck pains improved significantly, and motor or sensory deficits disappeared or improved in varying degrees after surgery. Neurologic function level of the patients improved by 1 to 3 grades based on the Frankel grading system 3 months after surgery. All the internal fixations fused well, stability of the cervical vertebrae was secure, and no spinal instability was observed in our series.