4)   Is implicated in positive ACP-196 solubility dmso control of the G(1)/S phase transition     BAG3 (−1.1) Prevents FAS-mediated apoptosis     TP53INP1 (−0.9) Induces apoptosis     TOB (−0.3) Regulates cell growth 6-3 weeks ZNF490 (2.4)   Negative effect on cell cycle progression and promotes apoptosis   CARD11 (0.4)   Activates caspases that 4SC-202 play a central role in

apoptosis   PTHLH (0.4)   Positive and negative regulator of cell proliferation     FAF1 (−1.1) Increases cell death Sham Group       3-0 weeks MDM4 (1.9)   Potentially inhibits the G1 phase of the cell cycle   E2F2 (0.3)   Helps regulate the expression of a number of genes that are important in cell proliferation   WWOX (0.2)   Negatively regulates the progression through the cell cycle   UMOD (0.9)   Negative regulator of cell proliferation     BRCA1 (−0.6) Regulate cell-cycle progression,

DNA damage repair, cell growth and apoptosis     SKI (−0.3) Regulates cell proliferation 6-0 weeks TPX2 (0.3)   Involved in cellular proliferation   MDM4 (2.0)   Potentially inhibits the G1 phase of the cell cycle   CLU (0.4)   Regulates apoptosis   PROP1 (0.4)   Negatively regulates apoptosis     CCND2 (−0.3) May play a distinct NVP-LDE225 role in cell cycle progression     SOCS2 (−0.9) Regulates cell proliferation by terminating the transcription activity 6-3 weeks SKI (0.3)   Regulates cell proliferation     PECR (−0.5) Regulates apoptosis     BTG3 (−0.9) Is an anti-proliferative gene Control Group       3-0 weeks ESR1 (0.6)   Transcription factor binding     BMP2 (−2.8) Negatively regulates the progression through cell cycle     E2F2 (−0.4) Helps regulate the expression of a number of genes that are important in cell proliferation     FGF8 (−0.6) Regulates progression through cell cycle 6-0 weeks BMPR2 (0.7)   Regulates progression through cell cycle   CIB1 (0.5)   Signalling cell death   MPHOSPH9 (0.6)   Regulates progression through cell cycle via M- phase of mitosis   ELMO1 (0.4)   Promotes phagocytosis, cell shape changes and apoptosis 6-3 weeks DLEC1 (1.0)   Negatively regulates cell proliferation     EML4 (−0.3) Is significantly overexpressed in mitotic

cells     PARD6G (−0.4) Is involved in cell cycle and cell division When comparing gene expressions at three and six weeks with gene expression at time point 0 weeks, we found the resection group increasingly different over time from both the sham and control group (Figures 1, 2, 3). Acyl CoA dehydrogenase When comparing the three figures, seven genes were regulating apoptosis in the resection group, whereas only three and two in sham and control group, respectively. Figure 1 Differentially expressed genes in resection group at time contrast 3–0, 6–0 and 6–3 weeks. In resection group, more genes regulate apoptosis towards end of regeneration compared to sham and control group (Figures 2, 3). Figure 2 Differentially expressed genes in sham group at time contrast 3–0, 6–0 and 6–3 weeks. Figure 3 Differentially expressed genes in control group at time contrast 3–0, 6–0 and 6–3 weeks.