4%, 14.8%, 4.9% and 19.4%, respectively, although G1P[8] and G2P[4] prevalence was p38 MAPK signaling pathway relatively less during the present study. Among the other unusual G–P combinations, we found relatively similar percentages of rotavirus strains during the two study periods. Among the G genotypes, G12 and G9 were dominant during 2007–2012 with 21.2% and 20.6% prevalence respectively in comparison with 2000–2007

study which found G1 and G2 most common with 25.8% and 22.3% prevalence, respectively [17]. Among the P genotypes, we found P[4], P[6] and P[8] widely circulating during both the study periods. The striking difference was a high increase in the percentage of non-typeables which increased from 12.5% in 2000–2007 to 32.6% in 2007–2012. During the last 12 years, the surveillance study at AIIMS, Delhi has found

a seasonal distribution of rotavirus at varying frequency (Fig. 3). During autumn (Sep–Nov) and winter (Dec–Feb) we observed relatively high percentages of rotavirus infections in comparison with spring (Mar–May) and summer (Jun–Aug). In the winters of 2000–2004, 2005–2008 and 2009–2012 rotavirus infection rates peaked with detection rates of 58% (19/33), 82% (55/67) and 49% (64/131), respectively. In comparison, rotavirus prevalence during summer and spring season overall ranged from 16–44% to 12–39%, respectively. Studies have shown that worldwide rotavirus, like norovirus, is predominant during the dry winter period [18]. In the present study we observed year GPCR Compound Library round detection of rotavirus strains with distinct peaks during the winter season. Several other studies have reported similar observations [15], [19], [20] and [21]. A study from India by Chakarvati et al [22] reported high

detection of RV during the early winter months. Two more studies from Western India by Kelkar et al. [23] and [24] also reported winter season peaks for rotavirus gastroenteritis. Rotavirus genotyping data obtained in this study helps establish the genotypes prevalent in Delhi during the last 12 years. We observed continued predominance of G1, G2 and G9 genotypes with emergence of G12 as the fourth most common genotype during 2007–2012. A review by Miles et al [14] Megestrol Acetate on rotavirus diversity in the Indian subcontinent showed emergence of G9 and G12 with decline in percent detection of G3 and G4 strains. We observed similar results with rare detection of G3 and G4 genotypes during the last 12 years in Delhi. Although G1 and G2 have been globally prevalent, genotypes G9 and G12 are now emerging as dominant strains in various parts of the world [25], [26], [27], [28] and [29]. Among the P genotypes, all three common P types P[4], P[6] and P[8] were frequently detected as in our earlier studies [6] and [17]. Although P[4] and P[8] genotypes are common worldwide, P[6] genotype is commonly found in Africa and Asia [12], [13], [14] and [15].